Why Cortisone Shots Often Fail in the Knee

Knee Injection

When you’ve got nagging, persistent knee pain, it’s common for doctors to recommend a cortisone shot.

Cortisone shots, also known as corticosteroid injections, or “steroid shots”, work by reducing inflammation in your knee joint in an effort to alleviate pain.

Sounds pretty straightforward, right?

Well… not so fast.

Assuming your knee pain is truly due to inflammation, then yes, a cortisone shot can be a successful treatment option. For example, it’s often used as a pain management strategy when you’re awaiting a major joint replacement surgery.

Since severe, advanced osteoarthritis is a common cause of knee inflammation – and the only real “cure” for this is joint replacement – periodic cortisone shots may help give you the pain relief you need to pass the time until surgery.

But this is a very specific and not common circumstance. What we see more often than not is cortisone shots either working temporarily, or not working at all in your knee joint.

Patients are often told they need up to three cortisone shots to see results. But the problem with this approach is that every time you get a cortisone shot, you risk damaging the cartilage and tissue in your knee joint, which not only leads to irreversible joint damage, but more persistent pain in your joint that gets harder and harder to fix.

So when it comes to whether or not you should get a cortisone shot in your knee – you really want to make sure that the root source of your problem is inflammation.

The reason why so many cortisone injections “fail” is because quite often – they weren’t needed in the first place. Even though the knee pain you are experiencing might be due to inflammation, the underlying cause leading to that inflammation could be something else entirely. Eight percent of the time the knee pain you’re experiencing is due to a mechanical or movement problem.

So while the symptoms you’re experiencing could be inflammatory in nature, the root cause of your issue is not. A cortisone shot is not going to help your knee in this case. Or worse, you’ll get temporary relief that fools you into thinking it did, which only delays treatment that will give you the long-lasting relief you’re looking for.

So how do you know if you have a true inflammatory problem in your knee?

Let me explain.

Let’s say you have some arthritis and general wear and tear in your knee joint. You have good days and bad days. The pain comes and goes. Certain movements and exercises make your knee feel better while others seem to really aggravate it.

This is a pretty classic presentation of a mechanical knee problem. The mechanical issue (aka movement problem) in your knee can irritate certain structures within your knee joint (like a meniscus or ligament) and cause it to be inflamed.

If you go ahead and just inject cortisone into this knee, it might relieve the inflammation for a short time, but it won’t help the underlying movement problem. It’s only a matter of time before the cortisone wears off and the structures in your knee feel irritated again. Not only have you masked the problem, but now you risk creating actual damage to those structures from the cortisone. Studies have shown that repeatedly injecting cortisone into your knee (or any joint) can advance the formation of osteoarthritis.

Another interesting statistic is that 41% of knee pain has been shown to be coming from your spine – even when there is no back pain present.

In this case, your knee could really hurt and appear to be inflamed. If a doctor can’t find any real explanation for this from an X-ray or an MRI (because the real problem is coming from your spine), he or she may assume it’s just inflammation from wear and tear and suggest a cortisone shot. This is not going to help your knee and once again – you risk causing real damage to an otherwise healthy knee joint.

These are just a few examples of where cortisone shots are unnecessary and can go wrong when incorrectly prescribed. If you’ve recently had a cortisone shot in your knee and it didn’t work, it could very well be that you never actually needed it, or that the symptoms (inflammation) was being addressed instead of the underlying cause.

If you are considering a cortisone shot in your knee, it’s always a good idea to get a second opinion to make certain you really need it and that it’s the best course of action for your knee problem. A mechanical pain expert can tell you whether or not your knee pain is truly due to inflammation. If it turns out your knee pain is due to a movement problem (which 80% of time it is) then a proper movement prescription is your answer – not cortisone.

Are you local to the downtown DC area and looking for help with your knee pain NOW?

Consider speaking to a specialist at my clinic

Tell us about your knee pain and we’ll see if we would be a good fit to help you!

CLICK HERE to speak with a specialist at my clinic.

PS – Not ready to see a specialist but what to learn more about managing knee pain naturally without pills, procedures, or surgery? DOWNLOAD our Free Knee Pain Report

Free Knee Pain Report


Trupti Mehta, PT, MS, OCS

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